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Tag: Pharmaceutical

Mixers / Industrial Bicone Dryers

Written by michelapretto on . Posted in Powders/Solids.

C.L.A. bicone industrial mixers and dryers are vacuum systems designed for mixing and drying dry or wet powders. Because they are built to customer requirements, they are suitable for multiple industries and can also be made in Special alloys depending on the application.

Applications

I C.L.A. bicones find use in the processing of powders in various production areas:

  • Pharmaceutical industry: mixing of active ingredients and excipients
  • Food industry: processing of spices, additives and supplements
  • Chemical industry: fine powders, pigments and special substances
  • Cosmetics industry: make-up powders and talcum powders

Specifications

  • Type: double-cone dryers, which can also be used as vacuum mixers
  • Design on URS: made to customer specifications for process and application
  • Materials: Stainless steel; Special alloys construction possible as required
  • Automation: can be supplied with temperature control unit and dedicated accessories
  • Vacuum: provision with vacuum pump can be supplied on request
  • Accessories: possibility of additional configurations according to customer needs

Benefits

  • Versatility: usable for mixing and drying in various industries
  • Customization: made to URS and adaptable to specific process requirements
  • Quality of construction: selected materials and possibilities for Special alloys
  • Integration: provision for automation systems and accessories on request

FAQ

Can bicone mixers/dryers be used in multiple areas?

Yes, they find application in pharmaceutical, food, chemical and cosmetic fields.

Is it possible to request constructions in special materials?

Yes, depending on the application they can also be made of Special alloys as well as stainless steel.

Can the system be supplied with a vacuum pump?

Yes, the vacuum pump can be supplied with the machine as a dedicated accessory.

Are automation solutions available?

Yes, they can be supplied with temperature control unit and other accessories according to customer requirements.

See also.

Contact us to configure a bicone mixer/dryer tailored to your industrial needs.

Cleaning in Place (CIP) systems

Written by michelapretto on . Posted in Liquids.

Cleaning-in-Place (C.L.A.) systems ( CIP ) are complete systems for internal cleaning of process plants. Made to customer requirements, they integrate storage tanks, recirculation pumps, heat exchangers and valve automation, ensuring reliable and customized solutions.

Specifications

  • Design on URS: sizing and layout defined to customer specifications
  • Automation: semiautomatic panel or advanced solutions with PLC, recipe management and HMI touch
  • Materials: Stainless steel AISI 304, 316L, 904 and Special alloys (HC22, HC276, SAF)
  • Certifications: PED 2014/68/EU compliance; IQ/OQ documentation; FAT and SAT available upon request
  • Integration: provision for connection to plant utilities (CIP/SIP)

Benefits

  • Easy integration with existing facilities and utilities
  • Hygiene and traceability through design on URS and technical documentation
  • Scalable automation for repeatability and cycle control
  • Materials certified for strength and durability

Areas of application

I Cleaning in Place (CIP) systems are custom configured for lines and processes in different industries:

FAQ

Can CIP C.L.A.’s be integrated with site utilities?

Yes, the systems are prepared to be connected to plant utilities (CIP/SIP).

How are the CIPs structured?

They include storage tanks, recirculation pumps, heat exchangers and automation with related valves.

Is automatic control with PLC and recipe management available?

Yes, PLC, recipe management and touch HMI are available in addition to the semiautomatic panel.

What qualification documentation do you provide?

Documentation for IQ/OQ and, upon request, FAT and SAT.

What materials do you propose?

Stainless steels AISI 304, 316L, 904 and Special alloys HC22, HC276, SAF, selected according to URS.

Contact us to configure your Cleaning in Place (CIP) systems to URS specifications.

Condensers / Heat exchangers

Written by michelapretto on . Posted in Liquids.

C.L.A. Condensers / Heat exchangers are made in shell and tube design in different standard configurations (BEM, BEU, AES, etc.), designed on URS, and constructed of Stainless steel and Special alloys. Each piece of equipment is produced to order, with full certifications and documentation to ensure reliability and integration into industrial processes.

Specifications

  • Type: shell and tube exchangers type BEM, BEU, AES, etc.
  • Design on URS: custom sizes and configurations
  • Materials: Stainless steels AISI 304, 316L, 904; Special alloys HC22, HC276, SAF
  • Construction configurations: can be made in vertical or horizontal versions, made to order
  • Certifications: compliance with the PED Directive (2014/68/EU); corporate quality system UNI EN ISO 9001
  • Documentation: dimensional certificates, nondestructive testing (N.D.), pressure tests, roughness certificates; support for FAT, SAT, IQ and OQ

Benefits

  • Reliability: design and construction to URS specification
  • Certified materials: stainless and Special alloys for strength and durability
  • Standardized type: BEM, BEU, AES configurations ensure adaptability
  • Documented quality: PED, ISO 9001 and comprehensive technical certifications

Areas of application

C.L.A. condensers and heat exchangers find use in various production sectors.
Learn about the dedicated pages:

FAQ

What type of exchangers does CLA make?

CLA manufactures shell and tube exchangers, in standard configurations such as BEM, BEU, AES and equivalents.

What is the average lead time for a custom-made exchanger?

They depend on the complexity of the design and the materials chosen. The use of Special alloys may require longer lead times for procurement.

Does CLA also provide support during installation and startup?

Yes, the company supports the customer during FAT/SAT testing and can assist with plant start-up.

How much does the choice of configuration (BEM, BEU, AES, etc.) affect the performance of the exchanger?

Each configuration has specific advantages in terms of maintenance, cleanability, and process adaptability. The choice depends on the client’s URS.

 

Contact us to receive a customized proposal for your condensers or heat exchangers.

Condensate collection tanks

Written by michelapretto on . Posted in Liquids.

Condensate collection tanks C.L.A. are equipment designed and built to customer URS specifications. Made of Stainless steel and Special alloys, they adapt
to the requirements of processes in the chemical, pharmaceutical, food and cosmetic industries, ensuring quality and reliability over time.

What they are and what they are for

Condensate collection tanks have the function of containing condensate generated in industrial processes and are designed to integrate with process equipment according to the required technical specifications. Each implementation is customized, with dedicated engineering solutions.

Specifications

  • Design on URS: sizes, configurations and accessories defined according to customer needs
  • Materials of construction: Stainless steel AISI 304, AISI 316L, AISI 904 and special alloys (HC22, HC276, SAF)
  • Configurations: tanks available in vertical or horizontal versions, made to order
  • Certifications: equipment in compliance with PED Directive (2014/68/EU), with ISO 9001 certified company quality system since 1996
  • Documentation: issuance of dimensional certificates, nondestructive testing, pressure testing, roughness and others on request

Benefits

  • Full customization according to customer specifications (URS)
  • High-quality materials for strength and durability
  • Certified compliance with PED and ISO 9001
  • Comprehensive technical documentation in support of FAT, SAT, IQ and OQ

Areas of application

Condensate collection tanks C.L.A. find use in various production departments.
Learn about the dedicated pages:

FAQ

What does “design on URS” mean for a Condensate collection tanks?

It means that tank sizes, configurations, and fittings are defined on your User Requirement Specification (URS), so the equipment is built exactly according to your plant requirements.

Can I choose a vertical or horizontal version?

Yes. Tanks are made to order and available in vertical or horizontal configurations to suit the layout and available space.

What construction materials are available?

Stainless steels AISI 304, AISI 316L, AISI 904 and, when required by the process, Special alloys such as HC22, HC276, SAF.

What technical documentation comes with the tank?

Complete documentation is available: dimensional certificates, nondestructive testing, pressure testing, roughness certificates, and reports supporting FAT, SAT, IQ, and OQ.

What certifications do the tanks meet?

The equipment complies with the PED Directive (2014/68/EU) and is supported by a UNI EN ISO 9001-certified corporate quality system.

In what areas can I use condensate collection tanks?

The tanks are used in the chemical, pharmaceutical, food and cosmetics industries, with configurations developed according to URS for each specific production context.

Is it possible to customize attachments, connections and plant layout?

Yes. Designing on URS involves adapting connections, dimensions, and arrangements to the specifications of your system.
Contact us to receive a customized proposal and the most suitable configuration of your Condensate collection tanks.

Reactors

Written by michelapretto on . Posted in Liquids.

C.L.A. Reactors are reaction vessels designed and built to URS specifications, equipped with advanced heat exchange, stirring and automation systems. Ideal for the Chemical, Pharmaceutical, Food and Cosmetic sectors, they ensure safety, process control and customized customization.

What are Reactors

A reactor is a technical vessel in which a chemical or physical reaction takes place, equipped with systems for heating, cooling, and agitation of substances.

Applications in different sectors

  • Chemical industry: tailor-made plants for chemical synthesis, catalysis and transformation
  • Pharmaceutical industry: high-precision reactions for APIs and intermediates, with traceability and validation
  • Food industry: safe processes for food ingredients, with hygienic and thermal control
  • Cosmetic industry: Reactors suitable for the production of gels, creams and cosmetic solutions

Why choose C.L.A. Reactors.

  • Design on URS: customization according to flow rate, temperature, viscosity and process.
  • Selected materials: AISI 304, 316L, 904 steels and special alloys (HC22, HC276, SAF).
  • Modular heat exchange: jacket, half-pipe or inner coil.
  • Customized agitation: anchors, turbines, impellers for optimized mass transfer.
  • Integrated automation: complete skids with PLC, valves, process control instruments.
  • Certifications: PED compliance, ATEX, ISO 9001 and complete technical documentation.

Integrated Services

We offer complete engineering support: from shop floor sizing, mechanical design, FAT/SAT testing, to customer commissioning.

Explore dedicated solutions

Reactors for the chemical industryReactors for the pharmaceutical industryReactors for the food industry

Reactors for the cosmetics industry

FAQ

What is the difference between a chemical and a pharmaceutical reactor?

Chemical Reactors are designed to withstand extreme conditions (pressure, corrosion, aggressive reagents), while pharmaceutical Reactors prioritize hygiene, document validation, and process traceability.

What parameters are critical in choosing a reactor?

Usable volume, operating pressure and temperature, compatibility of materials of construction, type of agitation, and automation/control systems.

Can a reactor be customized on URS?

Yes, C.L.A. Reactors are sized and configured according to User Requirement Specifications (URS), with a choice of geometries, accessories and automation systems.

What certifications are required for industrial Reactors?

The main ones are PED Directive (Pressure Equipment Directive (2014/68/EU)), ATEX (explosion hazard zones) and ISO 9001 for quality. FAT, SAT, IQ and OQ are also required in pharmaceuticals.

How long is the useful life of a reactor?

Dependent on materials, operating conditions, and maintenance, Stainless steel and Special alloys Reactors can provide decades of use with preventive maintenance and periodic inspections.

Is it possible to integrate a reactor into an existing plant?

Yes, through complete skids with automation (PLC, valves, instruments) that facilitate insertion into already operational production lines.

Contact us to define together your ideal reactor configuration for your industry.

Industrial hydrogenators

Written by michelapretto on . Posted in Liquids.

C.L.A. Industrial hydrogenators are equipment designed and built according to customer URS specifications, ideal for complex processes in the chemical and pharmaceutical industries. With the ability to configure materials, heat exchangers and agitation systems, they ensure reliability, safety and process customization.

Applications

  • Hydrogenation reactions in chemicals and pharmaceuticals
  • Processes requiring high pressure and thermal control
  • Productions requiring fully PED and ATEX certified systems
  • Integration into complex plants via complete automation skids

Specifications

  • Materials of construction: Stainless steel AISI 304, AISI 316L, 904; Special alloys HC22, HC276, SAF
  • Heat exchange systems: jacket, half-pipe, inner coil
  • Agitation systems: anchor, turbine, impeller (customized according to process)
  • Watertight tank-in-tank type insulation for thermal insulation
  • Complete skids with automation (PLC, valves, instruments and various accessories)
  • Certifications: PED 2014/68/UE, ATEX

Automation and control

C.L.A. hydrogenators can be supplied in automated skid versions, complete with PLC, valves, instruments and accessories, ensuring safe and efficient control of process parameters.

FAQ

What materials are available for construction?

Stainless steels AISI 304, AISI 316L, 904 and Special alloys such as HC22, HC276 and SAF.

What heat exchange systems are planned?

Jacket, half-pipe or inner coil, selected according to the process.

What types of agitation are possible?

Again, turbine or impeller, custom configured.

Are hydrogenators certified?

Yes, in accordance with the PED Directive (2014/68/EU) and ATEX.

Is an automation system available?

Yes, with skids complete with PLC, instruments and accessories for automatic control of process parameters.

See also.

Contact us to receive technical advice and the most suitable configuration for your process needs.

Fermentation systems

Written by michelapretto on . Posted in Liquids.

Complete solutions for pharma, chemical and food

Our Fermentation systems transform raw materials into final solutions that can be used in the pharmaceutical, chemical and food industries. Designed to customer measurements to ensure versatility, hygiene and process control, they cover the entire cycle, from the fermenter to the final stage of production.

Specifications

  • Volume: 5 – 3000 L
  • Stirring: from the top or bottom, including magnetic transmission for maintaining sterility
  • Heating/cooling: thermal jacket with recirculation and on-board steam (optional)
  • CIP/SIP: prepared and connectable to utilities or on-board
  • Control panel: semi-automatic, with PLC option, recipes, touch-screen and batch recording
  • Pumps and valves: metering, recirculation, sterile valves, sterile gas filters
  • Documentation: PED 2014/68/EU, IQ, OQ, FAT, SAT upon request
  • Approval pressures: body 1+4 bar, liner 1+3 bar

Fermentation process and control

  • Control key parameters: pH, temperature, aeration, agitation
  • Automatic recording to ensure quality and batch traceability
  • Sterile process gas filters and integrated lid lifting system
  • Possibility of integration with on-board steam generator

Applications by industry

  • Pharmaceutical: microbial and bacterial ferments, APIs, biopharmaceuticals, vitamins
  • Chemical: bioproduction of enzymes, bio-solvents, industrial intermediates
  • Food: production of yogurt, probiotics, supplements and fermented drinks

FAQ

What sizes do you cover?

From 5 L prototypes to 3000 L industrial-scale fermenters.

How is sterility guaranteed?

With magnetic stirring, sterile gas filters, CIP/SIP and certified pressure.

Can I integrate batch management with SCADA?

Yes, with PLC option and touch screen, recipe management and data storage.

Is it possible to connect it to my existing system?

Yes, compatible with plant utilities or on board machine.

See also.

Tablet coating preparation systems – solutions for creams and gels

Written by michelapretto on . Posted in Creams/Gels.

Tablet coating preparation systems for pills from C.L.A. are designed for handling and preparing denser formulations such as gels and creams to be applied to pills or capsules, via bassine or coating systems. Particularly suitable for cosmetic and pharmaceutical environments, they ensure thermal control, product homogeneity and complete sanitizability.

Applications

  • Preparation of filming or polishing creams and gels for pill coating
  • Viscose-based formulations for functional and sensory coatings
  • Small batch production for coating department or laboratory

Specifications

  • Capacity: 10 to 300/350 liters
  • Stirring: from above or below, with the possibility of magnetic drag
  • Heating: hot water circuit with electric heating elements
  • Cooling: by mains water
  • Sanitization provision: CIP/SIP, fully washable
  • Certifications: PED 2014/68/EU, IQ/OQ, FAT, SAT upon request

Automation and control

  • Semi-automatic control panel
  • PLC option with recipe management, temperature, time and touch screen interface

FAQ

Is it suitable for processing thick gels or creams?

Yes, it is designed to ensure homogeneity and thermal control even on high-viscosity products.

Can prescription management be automated?

Yes, with the PLC and touch panel option you can set and save preparation recipes.

How does the temperature control take place?

Through circuit with hot water and integrated probes for precise thermoregulation.

See also.

Tablet coating preparation systems for pills – liquid solutions

Written by michelapretto on . Posted in Liquids.

C.L.A. Tablet coating preparation units are mobile preparation systems specifically designed for the preparation of liquid solutions intended for coating pills in bassines. Ideal for the pharmaceutical and cosmetic industries, they offer hygiene, precision and ease of use in the production of film-forming lacquers, functional coatings and ready-to-use liquid solutions.

Applications

  • Preparation of liquid solutions for bassin coatings
  • Production of film-forming lacquers, dyes, polishing solutions
  • Use in pharmaceutical and cosmetic environments for small batches

Specifications

  • Capacity: 10 to 300/350 liters
  • Stirring: from above or below, magnetic or traditional dragging
  • Heating: electric heaters + hot water circuit
  • Cooling: connection to mains water
  • Washing: fully washable and CIP/SIP-ready
  • Certifications: PED 2014/68/EU compliance; IQ/OQ, FAT, SAT upon request

Automation and control

  • Semi-automatic control panel
  • Option: automatic management with PLC, touch screen and recipe control

FAQ

Is it suitable for all kinds of liquid lacquers?

Yes, it is designed for water- or solvent-based solutions that are compatible with functional or aesthetic coatings.

Can I use the plant in GMP environments?

Yes, it complies with pharmaceutical and cosmetic standards and prepared for CIP/SIP sanitization.

Is automatic control available?

Yes, you can choose the option with PLC, parameter management and touch screen.

See also.

Preparation systems for liquids/gel and powders

Written by michelapretto on . Posted in Creams/Gels, Liquids.

Preparation and storage systems made by C.L.A. are designed to process liquid, semidense, gel and liquid/dust mixtures in a controlled environment. Ideal for cosmetic and pharmaceutical production, the plants work in batches and include tanks, agitators and full automation.

Specifications

  • Capacity: from 10 liters up to 3000 liters
  • Applications: injectables, oral, syrups, lavages, gels, creams
  • Internal finish: Ra < 0.5 µm to ensure hygiene and cleanliness
  • Materials: Stainless steel AISI or Special alloys
  • Stirring: from the top or bottom, also magnetic drive for sterility and reduced maintenance
  • Heating: electric heaters and jacket with temperature control
  • PED approval: 2014/68/EU with pressures 1+6 in body, 1+3 in jacket
  • Certifications: IQ, OQ, FAT, SAT available upon request

Components and accessories

  • Vacuum pump
  • Load cells for weighing
  • Heating liquid recirculation pump
  • Transfer pump
  • CIP/SIP linkability to plant utilities.

Automation and control

  • Semi-automatic control panel
  • Optional: automatic management via PLC
  • Recipe management and process parameters
  • Thermoregulation management, recording and printing
  • HMI Panel

Areas of application

  • Pharmaceutical: sterile and non-sterile liquid preparations, oral solutions, gels
  • Cosmetic: emulsions, creams, gels, lotions, liquid/powder-based products

FAQ

How much capacity do your facilities cover?

From 10 to 3000 liters per plant, with scalable batch configurations.

Can I manage recipes and parameters automatically?

Yes, through integration with PLC and touch panel, recipes, temperature, timing and data printing can be controlled.

Can the plant be connected to the plant’s CIP/SIP system?

Yes, all models are prepared for direct connection to existing utilities.

Is support for qualification included?

Yes, we issue IQ, OQ, FAT, SAT documents complying with industry standards upon request.

See also.

Where the process takes shape

We support you in designing and building the plant that best suits your needs. Precision, experience and Custom solutions from the first meeting to delivery.

Contact us for a consultation

CLA SRL | Via Vicenza, 2 - 36015 Schio (VI) Italy | Tel. +39 0445 673030 | Mob. +39 338 5327599 | Email: cla@claschio.it | VAT IT00545840241 | SDI code: T04ZHR3 | Vicenza Companies Register no. 136196 | Fully paid-up share capital € 300.000 | Web Agency Vicenza‎ | Sitemap | Privacy policy | Cookie policy